Mean (SD) number of lesions before and after intervention in group D was 15 (7.4) and 11.1 (6), respectively ( P <0.0001). Mean (SD) number of lesions before and after intervention in group M was 17.6 (7.7) and 12.5 (7.4), respectively ( P <0.0001). Mean (SD) VAS score before and after intervention in group D was 6.6 (1.8) and 5.7 (1.9), respectively ( P <0.0001). Mean (SD) VAS score before and after intervention in group M was 6.9 (2.0) and 5.3 (2.1), respectively ( P <0.0001). Mean IGA score, mean number of lesions and mean VAS score were not significantly different between the two groups, whether before, during or after intervention. CONCLUSION: Dapsone gel was as effective as metronidazole gel in the treatment of papulopustular rosacea. J Drugs Dermatol . 2015;14(6):602-606.