P98- human adipocyte derived mesenchymal stromal cell supports keratinocyte growth in a modified collagen- hyalorunic acid matrix

Abstract objective: skin loss can occur due to many reasons including burns, diabetic wounds, venous ulcers, trauma, genetic disorders and etc…. although much progress has been made towards the development of skin engineering but these are not completely efficient and require to improvement. it is known that many types of cells including fibroblasts and bone marrow stem cells improve performance of composite skin substitutes. here we worked on an autologous construct as a successful skin substitute by culture of human adipocyte derived mesenchymal stem cells (hadmsc) and human keratinocytes on the hyalorunic acidcollagen matrix (ha-col)