A comparison between intralesional hypertonic sodium chloride solution and meglumine antimoniate (glucantime) injections in the treatment of cutaneous leishmaniasis

Background and objective: Different local and systemic modalities are suggested in the treatment of cutaneous leishmaniasis, but the pentavalent antimony compounds are still considered as the first line of treatment. Regarding to increase in clinical drug resistance and adverse effects, efforts to find a more effective and safer drug is continuing. The objective of this study was to compare the effect of intralesional hypertonic sodium chloride solution and intralesional meglumine antimoniate injections in the treatment of cutaneous leishmaniasis Materials and Methods: This randomized controlled clinical trial with simple sampling method was performed on 72 patients with cutar.eous leishmaniasis. The patients were randomly divided in two groups. One group was treated with intralesional hypertonic sodium chloride solution and the other one was treated with intralesional meglumine antimoniate injections at weekly intervals for 6 to 10 weeks. All patients were followed for 6 months after treatment