کـلـیـنـیـک تخصـصـی
پوسـت، پیوند مو و لیزر

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Date of Release: 2014

Cell Therapy for Dermal Reconstruction

Skin is the largest organ of human which plays a critical role in different functions of the human body, such as homeostasis, sensory detection, protecting against external insults, and healing. Skin is consisted of thin epidermis and relatively acellular dermis of  collagenrich extracellular matrix (ECM) (1). One of the major applications of tissue-engineered skin substitutes in wound healing is to promote cutaneous wound healing. The skin wounds can be caused by mechanical trauma, surgical procedures, reduced blood  irculations, burns, or aging procedures. Most of the skin wounds can heal naturally, but additional surgery requires immediate coverage, using skin substitutes, to facilitate skin repair and regeneration, in cases with extensive or irreversible skin damages (2). However,  the available skin substitutes often cause a range of problems including wound contraction, scar formation, and poor integration to the underlying host. Engineering the skin substitutes through tissue engineering approaches has relied upon the creation of three-dimensional scaffolds to guide cell adhesion, growth, and differentiation to form functional and structural tissues (3)
Cell Therapy for Dermal Reconstruction
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