Results: Numbers of the patients that achieved complete cure at week 16 were 22 patients (40%), 20 patients (36.4%) and 36 patients (65.5%) for concentrated boiled extract of Cassia fistula, hydroalcoholic extract of Cassia fistula and intralesional injection of MA, respectively. The efficacy of the intralesional injection of MA was significantly more than that of the concentrated boiled extract of the Cassia fistula (P = 0.02). Also, the efficacy of the intralesional injection of MA was significantly more than that of the hydroalcoholic extract of the Cassia fistula (P = 0.005). There was no significant difference between the efficacy of concentrated boiled extract and that of the hydroalcoholic extract of the Cassia fistula (P = 0.61)
Conclusion: Our study showed that almost 40% of the patients treated with this plant achieved complete cure of the lesions. We propose further evaluation of the effect of combined intralesional injection of MA and topical therapy with this plant to assess the accelerating resolution of the leishmaniasis ulcer and to possibly decrease the dose of MA