Date of Release: 2012

Evaluation of Anti- DSG1 Antibody in Cutaneous Leishmaniasis Patients

Abstract: Background: Pemphigus foliaceus (PF) is a cutaneous autoimmune bullous disease characterized by the presence of anti-desmoglein 1 antibodies. The trigger for the formation of these antibodies is thought to consist of the vector insects of parasitic diseases found in endemic regions for PF, including leishmaniasis, as a non-pathogenic variant of these antibodies was found in patients with those parasitic diseases in endemic regions for PF. This hypothesis would be confirmed by the finding of the said non-pathogenic antibodies in patients with one of these parasitic diseases in regions non-endemic for pemphigus foliaceus. Therefore the aim of this study was the evaluation of Anti-DSG1 antibody in patients suffering to zoonotic cutaneous leishmaniasisin Isfahan city of Iran. Methods: Blood sera of 58 patients with zoonotic cutaneous leishmaniasis, confirmed by clinical signs and direct blood smear, were collected and enzyme-linked immunosorbent assay (ELISA) for anti-desmoglein 1 antibodies was performed on these sampl. Findings: 56 out of 58 serum samples of patients with cutaneous leishmaniasisin this study were negative for anti-Dsg1 antibodies using ELISA, with one sample having an indeterminate value and one sample being positive. Conclusion: Our results reject our initial hypothesis regarding the role of leishmaniasisin triggering the formation of anti-desmoglein 1 antibodies. Several alternate explanations are possible, including the role of the black fly Simuliumnigrimanum (English). Copyright of Journal of Isfahan Medical School is the property of Isfahan University of Medical Sciences, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract
Evaluation of Anti- DSG1 Antibody in Cutaneous Leishmaniasis Patients
Leave a Reply

Your email address will not be published. Required fields are marked *

Search