Graphical abstract
In a hair follicle, keratinocytes and melanocytes respectively originate from the surface ectodermal and neuroectodermal embryonic layers. The origin of the dermis is dependent on its location in the body. The face and scalp dermis is developed from neural crest. Thus, hair follicle dermal papilla, dermal sheath, and mesenchymal cells are also formed from neural crest. Nanomedicine is able to facilitate hair follicle regeneration by stimulating specific cells. Nanomedicine offers a platform for the incorporation of useful biological molecules for the regeneration of hair follicle. It is expected that this growing technology will play a critical role in the advancement of hair regeneration in the near future