Skin Tissue Engineering

introduction: the skin, which is the largest tissue in human body, is constructed of three layers epidermis, dermis and hypodermis. it performs a main function in protecting the human body from much chemical and mechanical damage from the surrounding environment. the loss of skin can occur for various reasons, such as thermal trauma, genetic disorders, chronic wounds, burns or even surgical interventions. because of the low immunogenicity of donor skin and the limited availability of donor skin sources, skin grafts are unable to provide complete recovery of the skin rendering them unsuitable for widespread use. amniotic membrane has been employed in the treatment of wounds for almost 100 years, beginning with early application of natural amniotic membrane obtained from labor and delivery to various types of burns and wounds. amniotic membrane (am), the most internal placental membrane, has unique properties including anti adhesive effects, bacteriostatic, wound protection and pain-reduction properties, as well as epithelialization initialization capacities. am is widely available and less costly than other bioengineered skin substitutes

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